Tatum's 36 lifts Boston past the defending champions at TD Garden.
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14-of-26 shooting, 9 rebounds, 7 assists and 3 steals in Boston's home opener.
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New York cut a 12-point deficit to one before Tatum answered with two late baskets.
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Karl-Anthony Towns led the Knicks, but Boston held on for the 107-103 win.
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Boston's new signing chipped in 15 as the Celtics found secondary scoring.
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Neemias Queta matched George with 15 in a balanced Boston effort.
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Miles McBride scored 20 off the bench, but the Knicks still fell to 0-2.
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Boston bounces back from an opening-day loss to Detroit with its first win.
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New York is the first defending champion to start 0-2 since Dallas in 2011-12.
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OG Anunoby scored 20, but four Knicks scoring 19-plus was still not enough.
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The Celtics look to build on the win; the Knicks need their first victory soon.
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Full report, stats and FAQ: Celtics beat Knicks 107-103. Follow The Nerdy Humourist for more.
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